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催产素受体与肿瘤 被引量：4

Oxytocin receptor and tumor
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摘要 Oxytocinreceptor(OTR)isamemberofG -proteincoupledreceptor ,whichhasbeen foundinmanytumorsandcancercelllines .Manystudiesrevealedoxytocin(OT)mayinhibitthetumorand cancercellgrowthandproliferation ,butthemechanismofthisinhibitionisnotwellknown .Someexperiments indicatedcAMP -PKAsystemparticipatesinthesignaltransductionthatoxytocininhibitsthecancercellpro liferation .However ,otherexperimentsshowedthesignaltransductionforoxytocinintheHs5 78Tcarcinosaco macellisthesameasthatinthenormalcells .Inthisreview ,therelationshipbetweenOTRandtumorsare summarized . [ Oxytocinreceptor(OTR)isamemberofG -proteincoupledreceptor ,whichhasbeen foundinmanytumorsandcancercelllines .Manystudiesrevealedoxytocin(OT)mayinhibitthetumorand cancercellgrowthandproliferation ,butthemechanismofthisinhibitionisnotwellknown .Someexperiments indicatedcAMP -PKAsystemparticipatesinthesignaltransductionthatoxytocininhibitsthecancercellpro liferation .However ,otherexperimentsshowedthesignaltransductionforoxytocinintheHs5 78Tcarcinosaco macellisthesameasthatinthenormalcells .Inthisreview ,therelationshipbetweenOTRandtumorsare summarized . [
作者 崔瑞耀 王永久 由振东
机构地区 青岛大学医学院病理生理学教研室 第二军医大学神经生物学研究室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2003年第4期554-557,共4页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目 (No .39870 871)
关键词 催产素 受体 肿瘤 信号转导 Receptor,oxytocin Neoplasmas Signal transduction
分类号 R730.23 [医药卫生—肿瘤]
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参考文献29

  • 1[1]Cassoni P,Sapino A,Negro F,et al. Oxytocin inhibits proliferation of human breast cancer cell lines[J]. Virchows Arch,1994,425(5):467-472.
  • 2[2]Cassoni P,Sapino A,Fortunati N,et al. Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A[J]. Int J Cancer,1997,72(2):340-344.
  • 3[3]Tadashi Kimura, Osamu Tanizawa, Kensaku Mori, et al. Structure and expression of a human oxytocin[J]. Nature, 1992,356(9):526-529.
  • 4[4]Tomoko Inoue, Tadashi Kimura, Chihiro Azuma, et al. Structural organization of the human oxytocin receptor gene[J]. J Biol Chem,1994,269(51):32451-32456.
  • 5[5]Florence Rozen, Caterina Russo, Denis Banville, et al. Stucture, characterization, and expression of the rat oxytocin receptor gene[J]. Proc Natl Acad Sci, 1995,92(1):200-204.
  • 6[6]Kubota Y, Kimura T, Hashimoto K, et al. Structure and expression of the mouse oxytocin receptor gene[J]. Mol Cell Endocrinol, 1996,124(1):25-32.
  • 7[7]Bathgate R, Rust W, Balvers M, et al. Structure and expression of the bovine oxytocin receptor gene[J]. DNA Cell Biol, 1995,14(12):1037-1048.
  • 8[8]Valentin Gorbulev, Hubert Buchner, Aida Akhudova, et al. Molecular cloning and functional characterization of V2[8-lysine] vaspression and oxytocin receptor from a pig kidney cell line[J]. Eur J Biochem, 1993,215(1):1-7.
  • 9[9]Elands J, Van Dooremalen E, Spruyt B, et al. Oxytocin receptors in the hypothalamic ventromedial nucleus: a study of possible mediators of female sexual behavior[A]. In:Jard S, Jamison R. eds. Proceeding of the third vasopressin conference [M]. MontpellierJohn Libbey, 1991.447-466.
  • 10[10]Chan WY, Chen DL, Manning M. Oxytocin receptor subtypes in the pregnant rat myometrium and decidua: pharmacological [J]. Endocrinology, 1993,132(3):1381-1386.

同被引文献38

  • 1张秀枝.腹腔镜治疗输卵管妊娠156例及手术技巧总结[J].实用妇产科杂志,2005,21(9):565-566. 被引量：18
  • 2赵智,杨际超,管东东,杨彩燕,杨爽.初发输卵管妊娠的合理治疗预防再次输卵管妊娠[J].滨州医学院学报,2006,29(6):471-472. 被引量：1
  • 3谢咏,王刚,林铁成,郑丽丽,吴浩泉.输卵管妊娠患者腹腔镜保守性手术后生育状况及其影响因素分析[J].中国实用妇科与产科杂志,2007,23(6):433-436. 被引量：45
  • 4遇桂芳,曹蕾.腹腔镜下输卵管妊娠切开取胚术联合肾上腺素局部注射123例临床分析[C].中国第十四届内镜医学学术大会,2005.
  • 5Sueoka N.Intrastrand Parity Rules of DNA Base Composi-tion and Usage Biases of Synonymous Codons[J].J MolEvol,1995,40:318-325.
  • 6Knight R D,Stephen J F,Landweber L F.A Simple ModelBased on Mutation and Selection Explains Trends in Codonand Amino-acid Usage and GC Composition within andacross Genomes[J].Genome Biol,2001,2(4):1-13.
  • 7Moriyama E N,Powell J R.Gene Length and Codon UsageBias in Drosophila Melanogaster,Saccharomyces Cerevi-siae and Escherichia Coli[J].Nucleic Acids Res,1998,26(13):3188-3193.
  • 8D’Onofrio G,Mouchiroud D,Aissani B,et al.Correlationsbetween the Compositional Properties of Human Genes,Codon Usage,and Amino Acid Composition of Proteins[J].J Mol Evol,1991,32:504-510.
  • 9Moriyama E N,P owell J R.Codon Usage Bias and tRNAAbundance in Drosophila[J].J Mol Evol,1997,45(5):514-523.
  • 10Gupta S K,Majumdar S,Bhattacharya T K,et al.Studieson the Relationships between the Synonymous Codon Usageand Protein Secondary Structural Units[J].Biochem BiophysRes Commun,2000,269:692-696.

引证文献4

二级引证文献8

中国病理生理杂志
2003年 第4期

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