摘要
2- ( 4-硝基苯基 )乙胺经两次 N-烷基化反应、催化加氢还原和甲磺酰化制得抗心律失常药多非利特。具有合成步骤短、反应条件温和及选择性好等优点。总收率 46 .5 %。
A modified synthetic route for dofetilide was described. 2-(4-Nitrophenyl)ethylamine was N-alkylated twice followed by catalytic hydrogenation and methanesulfonylation to afford the product with an overall yield of 46.5%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第4期161-163,共3页
Chinese Journal of Pharmaceuticals
