老年骨质疏松性髋部骨折患者血清胰岛素样生长因子水平的研究

Study of IGF-Ⅰ Level in the Aged Osteoporotic Hip Fracture Patients

目的 :观察骨质疏松髋部骨折患者血清IGF Ⅰ浓度 ,与其它骨病老年人血清IGF Ⅰ水平作比较。方法 :骨质疏松性髋部骨折患者 32例 (股骨颈 17例、粗隆部骨折 15例 )及其它骨病老年患者 2 0例 (对照组 ) ,用放免方法测定血清IGF Ⅰ浓度。结果 :骨质疏松性髋部骨折组较对照组IGF Ⅰ下降 5 0 %左右。结论 :检测老年人IGF Ⅰ血清浓度可作为预测骨质疏松性髋部骨折的参考指标之一。

Objective:To observe the seurm IGF-Ⅰ level in osteoporotic hip fracture patients compared with other orthopaedic disease in the aged.Methods:Thirty-two patients with osteoporotic hip fractures were chosen.seventeen cases of them were femoral neck fractures and other 15 cases were transtrochanteric fractures.Twenty other orthopaedic disease patinets were used as controls.Results:The serum IGF-Ⅰ level in osteoporotic hip fracture groups are 50% lower than that of the controls.The means of IGF-Ⅰ in femoral neck group,transtrochanteric group and controls are 32.45±13.9 ug/L, 48.28±28.17 ug/L and 82.11±34.23 ug/L.Conclusion:The aged serum IGF-Ⅰ level may be used as a reliable sign for premonitoring osteopotic hip fracture.