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腺苷受体介导心脏延迟预处理的研究状况 被引量：1

Progress in the study of delayed preconditioning myocardial protection by adenosine receptors
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摘要 综述腺苷受体介导预处理延迟心肌保护的研究概况。激活心脏腺苷A1、A3 受体触发延迟预处理的信号传递 ,诱导保护性蛋白质表达及离子通道开放 ,从而减轻心肌缺血 再灌注损伤。 Adenosine receptor agonists can activate adenosine receptors A 1 and A 3, thus trigger delayed preconditioning signal pathway and induce high expression of protective proteins and some ionic channel opening in myocardial cells, which reduces myocardial ischemia/reperfusion injury.
作者 朱水波
机构地区 广州军区武汉总医院心胸外科
出处 《医学研究生学报》 CAS 2003年第3期222-223,共2页 Journal of Medical Postgraduates
关键词 腺苷 药物预处理 延迟保护 Adenosine Pharmacological preconditioning Delayed preconditioning
分类号 R654 [医药卫生—外科学]
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参考文献18

  • 1Baxter GF, Marber MS, Patel VC, et al. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning[J]. Circulation,1994,90:2993-3000.
  • 2Takano H, Bolli R, Tang X-L, et al. Activation of A1 or A3 receptors produces delayed protection against infarction in conscious rabbits by a mechanism involving KATP channels[J]. Circulation,1999,100:I-56.
  • 3Rizvi A, Tang X-L, Qiu Y, et al. Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning in conscious rabbits[J]. Am J Pyhsiol,1999,277:H874-H884.
  • 4Dana A, Jonassen AK, Yamashita N, et al. Adenosine A1 receptor activation induces delayed preconditioning in rats mediated by manganese superoxide dismutase[J]. Circulation,2000,101:2841-2848.
  • 5Zhao T, Xi L, Chelliah J, et al. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A1 receptors: evidence from gene-knockout mice[J]. Circulation,2000,102:902-907.
  • 6Kodani E, Tang X-L, Xuan Y-T, et al. Role of cyclic guanosine monophosphate in nitric oxide-dependent late preconditioning in conscious rabbits[J]. Circulation,2000,102(Suppl Ⅱ): Ⅱ-270.
  • 7Dana A,Yamashita N, Baxter GF, et al. Involvement of protein kinases and manganese-supetoxide dismutase in adenosine induced delayed preconditioning[J]. J Mol Cell Cardiol, 1998,30:A75.
  • 8Baxter GF, Yellon DM. ATP-ssensitive K+ channels mediated the delayed cardioprotective effect of adenosine A1 receptor activation[J]. J Mol Cell Cardiol, 1999,31:981-989.
  • 9Heads RJ, Baxter GF, Latchman DS, et al. Hsp and cytoskeletal protein expression and localization during delayed preconditioning in the rabbit heart[J]. J Mol Cell Cardiol,1998,30:A20.
  • 10Dana A, Skarli M, Papakrivopoulou J, et al. Adenosine A1 receptor induced delayed preconditioning in rabbits: induction of p38 MAPK activation and Hsp27 phosphorylation via a tyrosine kinase and protein kinase C-dependent mechanism[J]. Circ Res, 2000,86:989-997.

同被引文献4

  • 1[1]Baxter GF,Yellon DM.Time coure of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit[J].J Cardiovasc Pharmacol,1997,29(5):631-638.
  • 2[2]Meldrum DR,Cleveland JC,Rowland RT et al.Early and delayed preconditioning:differential mechanisms and additive protection[J].Am J physiol,1997,273(2pt2):H725-733.
  • 3[3]Xuan YT,Tang XL,Banerjee S et al.Nuclear factor κB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits[J].Circ Res,1999,84(9):1095-1109.
  • 4[5]Zhang J,Bolli R,Tang XL et al.Direct demonstration of both tyrosine and serine phosphorylation of IkBα during ischemic preconditioning in conscious rabbits[J].Circulation,1999,100(Suppl):I-56.

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医学研究生学报
2003年 第3期

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