5-氟-2-溴苯甲酸的制备实验研究

Synthesis of 2-Bromo-5-Fluorobenzoic Acid

以醋酸做溶剂 ,醋酸钴、醋酸锰、溴化钠做催化剂 ,用氧气常压氧化 5 -氟 - 2 -溴甲苯制备 5 -氟 - 2-溴苯甲酸 ,反应温度 1 2 0～ 1 30℃ ,物料浓度 1 6 .8%～ 2 0 .2 % ,催化剂用量为物料的 2 .5 %～ 4 %时 。

Under common air presure,2-bromo-5-fluorotoluene is oxidized by oxygen to synthesize 2-bromo-5-fluorobenzoic acid.Acetic acid is used as solvent;acetic cobalt,acetic manganese and bromide sodium are used as catalyzer.Reaction temperature ranging 120～130℃,2-bromo-5-fluorotoluene concentration ranging 16.8%～20.2% and the catalyzer dosage ranging 2.5%～4% of 2-bromo-5-fluorotoluene,the production ratio is high.