进口与国产流感疫苗血清学免疫效果对比

Compare Immune Effects of the Imported and Native Influenza Vaccines in Serology

目的 了解进口流感疫苗与国产流感疫苗对中国健康人群的血清学免疫效果 ,为流感疫苗的使用选择提供科学依据。方法 选择中国北方较为广泛使用的进口和国产 2种疫苗 ,分别接种于 2组健康人群 ,在免疫后不同时间 ,检测其抗体滴度 ,计算抗体保护率。结果 仅乙型抗体几何平均滴度 (GMT)在免疫后 15 0d ,2组差异有显著性 (t =2 0 339,P <0 0 5 ) ,2种疫苗在免疫后各时期 ,其抗体保护率差异均无显著性。甲1型和甲3 型抗体GMT在免疫后各时间差异无显著性。结论

Objective To understand the immune effects of the imported influenza vaccine and native influenza vaccine in serology on Chinese healthy people and supply the scientific proofs for the alternative of the influenza vaccines Methods The author chose the imported and native vaccines that had been used widely in north China and separately vaccinated two groups of healthy people At the different phases after immunization the author detected its antibody titer,computing its antibody protective rate Results Only the geometrical mean titer(GMT)of type Beijing/184 antibody appeared statistically significant difference in two groups 150 days after immunization( t=2 0339,P<0 05 ) The antibody protective rate of the two kinds of vaccines had no statistically significant difference at every time after immunization GMT of type H 1N 1 and H 3H 2 antibody had no significant difference in the two kinds of vaccines at every time after immunization Conclusions It indicated that the immune effects of the two kinds of vaccines in serology were almost as the same