海洋红藻松节藻Rhodomela confervoides化学成分研究

Studies on the chemical constituents of the marine alga Rhodomela confervoides

目的:对采自青岛海滨的海洋红藻松节藻 Rhodomela confervoides进行化学成分研究。方法:各种色谱柱层析和IR、MS、~1H-NMR、^(13)C-NMR、DEPT等波谱解析技术。结果:从松节藻中分离得到5个化合物,其结构经过鉴定分别为:2,2′,3,3′-四溴-4,4′,5,5′-四羟基双苯基甲烷(Ⅰ)、2,2′,3-三溴-3′,4,4′,5-四羟基-6′-甲氯甲基双苯基甲烷(Ⅱ),2,3-二溴-4,5-羟基苯甲醇(Ⅲ)、2,3-二溴-4,5-二羟基-苯甲醛(Ⅳ)、2,3-二溴-4,5-二羟基苯甲基已基醚(Ⅴ)。其中化合物Ⅱ对KB和Be17402肿瘤细胞有选择性细胞毒活性。

Objective Study on the chemical constituent of the marine red alga, Rhodomela confervoides, collected from the coast of Qingdao. Methods All kinds of column chromatog-raphy and IR, MS, NMR spectroscopic techniques were used. Results Five bromophenols have been isolated from the alga Rhodomela confervoides , and their structures were determined as 2,2', 3,3'-tetrabrorno- 4, 4', 5 , 5-tetrahydroxydiphenylmethane ( Ⅰ ), 2 , 2', 3-tribro-mo-3',4, 4', 5-tetrahydroxy-6'- hydroxymethyldiphenylmethane (Ⅱ), 2 , 3-dibromo-4, 5-di-hydroxybenzyl alcohol (Ⅲ), 2 ,3-dibromo-4,5-dihydroxybenzaldehyde (Ⅳ), 2 ,3-dibromo-4, 5-didroxybenzyl ethyl ether (Ⅴ). Among them, the compound Ⅱ showed selective antitu-mor activities against KB and Bel 7402 cells.