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癌基因蛋白c-erbB-2在子宫内膜癌中的表达 被引量:8

Expression of oncogene pritein c-erbB-2 in the endometrial carcinoma
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摘要 目的探讨子宫内膜癌中癌基因蛋白c-erbB-2、ER及PR的表达与临床病理特点的关系。方法应用免疫组化SP法检测28例子宫内膜癌中c-erbB-2、ER及PR的表达。结果28例子宫内膜癌中c-erbB-2、ER及PR的阳性表达率分别为53.57%(15/28)、67.85%(19/28)和60.71%(17/28)。c-erbB-2与ER、PR表达呈负相关,与子宫内膜癌病理分级是正相关。结论子宫内膜癌中c-erbB-2、ER及PR的表达可作为估计子宫内膜癌预后的重要指标。 Objective To investigate the relationship between the expression of c-erbB-2, ER and PR and the clinicopathologic character in endometrial arcinoma. Methods The expression of c-erbB-2, ER and PR in 28 cases of endometrial carcinoma were examined by SP immunohistochemical method. Results The rate of positive expression of c-erbB-2, ER and PR were 53.57% , 67.85% and 60.71%, respecti vely. The expression of c-erbB-2 was negative-correlated with that of ER and PR, and positive-correlated with the pathological grade of endometrial carcinoma . Conclusion The expression of c-erbB-2, ER and PR in endometrial carcinoma can be used as very important marks to assessing the prognosis.
作者 李惠
出处 《贵州医药》 CAS 2003年第4期302-303,共2页 Guizhou Medical Journal
关键词 子宫内膜癌 癌基因蛋白 C-ERBB-2 ER PR 免疫组织化学 预后 Endometrial carcinoma c-erbB-2 ER PR Immunohistochemisty
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  • 1回允中 主译.阿克曼外科病理学第8版[M].沈阳:辽宁教育出版社,1998.1625.

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