摘要
目的探讨子宫内膜癌中癌基因蛋白c-erbB-2、ER及PR的表达与临床病理特点的关系。方法应用免疫组化SP法检测28例子宫内膜癌中c-erbB-2、ER及PR的表达。结果28例子宫内膜癌中c-erbB-2、ER及PR的阳性表达率分别为53.57%(15/28)、67.85%(19/28)和60.71%(17/28)。c-erbB-2与ER、PR表达呈负相关,与子宫内膜癌病理分级是正相关。结论子宫内膜癌中c-erbB-2、ER及PR的表达可作为估计子宫内膜癌预后的重要指标。
Objective To investigate the relationship between the expression of c-erbB-2, ER and PR and the clinicopathologic character in endometrial arcinoma. Methods The expression of c-erbB-2, ER and PR in 28 cases of endometrial carcinoma were examined by SP immunohistochemical method. Results The rate of positive expression of c-erbB-2, ER and PR were 53.57% , 67.85% and 60.71%, respecti vely. The expression of c-erbB-2 was negative-correlated with that of ER and PR, and positive-correlated with the pathological grade of endometrial carcinoma . Conclusion The expression of c-erbB-2, ER and PR in endometrial carcinoma can be used as very important marks to assessing the prognosis.
出处
《贵州医药》
CAS
2003年第4期302-303,共2页
Guizhou Medical Journal