我国冠心病患者的血脂异常特点

Dyslipidemic feature in Chinese patients with coronary heart disease

目的 了解我国冠心病患者的血脂异常特点。方法 采用病例对照研究方法 ,调查 555例怀疑冠心病患者 (其中经冠状动脉造影确诊的冠心病患者 348例 ,非冠心病 2 0 7例 )的血脂异常情况 ,用标准方法检测血脂水平。结果 冠心病患者中高胆固醇血症发生率明显高于非冠心病患者 (2 2 .49%vs 1 6 .43 % ,P =0 .0 4 5) ,而其他脂质异常的发生率两组差别无统计学意义 ;冠心病组的总胆固醇、低密度脂蛋白胆固醇及脂蛋白 (a)水平显著高于非冠心病组[(4.96± 1 .1 6)mmol/Lvs (4.74± 1 .1 6)mmol/L ,P =0 .0 2 9;(3 .0 4± 1 .0 1 )mmol/Lvs (2 .74± 0 .93)mmol/L ,P =0 .0 0 1 ;(2 2 5 .6± 2 1 5 .1 )mg/Lvs (1 78.1± 1 4 9.3)mg/L ,P =0 .0 0 9] ,而高密度脂蛋白胆固醇则显著低于非冠心病组[(1 .0 3± 0 .35)mmol/Lvs (1 .1 2± 0 .39)mmol/L ,P =0 .0 1 1 ]。

Objective To investigate the dyslipidemic feature in Chinese patients with coronary heart disease(CHD).Methods 555 patients with suspected CHD were retrospectively studied by case control, who were divided into two groups according to the result of coronary arteriography:CHD group(n=348) and non CHD group(n=207). Each patient's serum lipids were detected by standard method, and the dyslipidemic type was recorded. Results Hypercholesterolemia occurs more frequently in the CHD group than that in non CHD group( 22.49 % vs 16.43 %,P= 0.047 ), there was not significant difference in other type of dyslipidemia between two groups. Compared with non CHD group,total cholesterol, low density lipoprotein cholesterol, and lipoprotein(a) levels in CHD group significantly elevated[( 4.96 ± 1.16 ) mmol/L vs ( 4.74 ± 1.16 ) mmol/L,P= 0.029 ;( 3.04 ± 1.01 ) mmol/L vs ( 2.74 ± 0.93 ) mmol/L,P= 0.001 ;( 225.6 ± 215.1 ) mg/L vs ( 178.1 ± 149.3 ) mg/L,P= 0.009 ], while high density lipoprotein cholesterol level significantly lowered[( 1.03 ± 0.35 ) mmol/L vs ( 1.12 ± 0.39 ) mmol/L,P= 0.011 ].Conclusion Hypercholesterolemia is a main feature of dyslipidemia in Chinese patients with CHD.