表皮生长因子不同用药方法对供皮区治疗的作用

Effect of epidermal growth factor treatment on skin graft donor site with defferent application methods

目的 探索外用重组人表皮生长因子治疗供皮区创面的最佳用药方法 ,以指导临床应用。方法 设生理盐水治疗为自身对照 ,选择三种用rhEGF的方法 (每日 1次法 ,每日 3次法 ,每日 1次加保湿法 ) ,进行供皮区创面愈合的比较性研究。结果 和对照组相比 ,rhEGF可有效促进供皮区创面愈合 (P <0 .0 1 )。三种用药方法之间比较 ,差别具有显著性意义 (P <0 .0 5) ,每日 1次加保湿法和每日 3次法均能进一步缩短创面愈合时间。结论 从方便、经济与合理的角度考虑 ,每日

Objective To explore the best method of applying recombinant human epidermal growth factor on skin graft donor site for the purpose of to guide its clinical application. Methods The skin graft donor sites were treated by rhEGF with three different application methods(once a day, three times a day and once a day with moistening). Normal saline was employed as the self-control agent. The wound healing time in each method was recorded and compared with each other. Results When compared with the self-control agent, the wound healing time was much shorter with rhEGF application(P<0.01). There were also obvious differences in the wound healing time with different methods(P<0.05). In addition, once a day with moistening and three times a day of rhEGF application cound further shorten the wound healing time. Conclusion In view of the convenience, economy and feasibility, once a day with moistening is recommended for the rhEGF clinical application.