腹水中α1-酸性糖蛋白测定的临床意义

Clinical significance of determination of ascitic α1-acid glycoprotein

目的 探讨测定腹水中α1 酸性糖蛋白 (AAG)的临床意义。方法 采用速率散射比浊法 ,对 80例渗出性腹水 (良性腹水 4 8例 ,癌性腹水 32例 )和 38例漏出性腹水进行血清和腹水AAG测定。结果 血清AAG :渗出液组 (14 0 .74± 6 7.39)mg/dl,其中良性腹水组 (12 4 .3± 72 .0 8)mg/dl,癌性腹水组 (16 5 .4± 5 1.4 7)mg/dl;漏出液组 (86 .3± 4 2 .5 2 )mg/dl;渗出液组与漏出液组间及良性腹水组与癌性腹水组间差异有显著性。腹水AAG :渗出液组 (70 .4 6± 35 .15 )mg/dl,其中良性腹水组 (5 7.3± 32 .4 2 )mg/dl,癌性腹水组 (90 .2± 2 9.75 )mg/dl;漏出液组 (2 0 .8± 2 2 .4 8)mg/dl;渗出液组与漏出液组间及良性腹水组与癌性腹水组间差异有显著性。结论 腹水AAG测定不仅能鉴别渗出液和漏出液 ,而且有助于对良恶性腹水的鉴别。

Objective To study the clinical significance of determination of ascitic α1-acid glycoprotein. Methods AAG in the serum and ascites was determined by raten nephelometry in all 118 patients. of all patients,80 patients with exudate (32 patients with malignant ascites,48 patients with nonmalignant ascites),38 patients with transudate.Results The value of serumal AAG:in patients with exudate and in patients with transudate was (140.74±67.39)mg/dl and(86.3±42.52)mg/dl, respectively. There was significant difference between exudate and transudate.in patients with malignant and in patients with nonmalignant was(165.4±51.47)mg/dl and (124.3±72.08)mg/dl, respectively. There was significant difference between malignant and nonmalignant. the value of ascitic AAG:in patients with exudate and in patients with transudate was (70.46±35.15)mg/dl and (20.8±22.48)mg/dl, respectively. There was significant difference between exudate and transudate.in patients with malignant and in patients with nonmalignant was( 90.2 ±29.75)mg/dl and (57.3±32.42)mg/dl, respectively. there was significant difference between malignant and nonmalignant. Conclusions Ascitic AAG values not only clearly separate exudate from transudate, but also discriminate between malignant and nonmalignant ascites.