模拟测定^(103)Pd放射性支架在血管中的剂量分布

Simulative study on dose distribution of ^(103) Pd stent in blood vessel

目的 测定血管内1 0 3Pd放射性支架的剂量分布。方法 采用肌肉组织等效材料代替血管壁 ,用热释光剂量计模拟测量血管内的剂量分布。结果 当支架活度为 9.8MBq时 ,支架表面累积吸收剂量为 9.8Gy(17d)。1 0 3Pd支架表面的剂量分布随径向距离增加而迅速减少 ,在支架表面径向距离 0 .4mm处 80 %的剂量被血管壁吸收。结论 血管内1 0 3Pd支架对血管周围的器官和组织无明显损害。

Objective To evaluate the dose distribution of 103 Pd stent in the blood vessel. Methods Simulative study on dose distribution of endovascular 103 Pd stent was conducted with thermoluminescence dosimeter. The vessel wall was substituted by muscle equivalent material in this simulative study. Results When radioactivity of the study 103 Pd stent was 9.8 MBq the absorbed dose from the stent surface by muscle equivalent material was 9.8 Gy at 17 d (the half life period of 103 Pd). The radioactivity of 103 Pd stent surface rapidly attenuated over the radial distance. 80% of the radioactivity at the area that was radially 0.4 mm apart from the stent surface was absorbed by the simulative blood vessel wall. Conclusion Endovascular 103 Pd stent does not exert significant injury on the surrounding organs or tissues.