咪唑斯汀治疗慢性特发性荨麻疹疗效分析

Analysis of effect of Mizolastine on Patients with Chronic Idiopathic Urticaria

目的 采用咪唑斯汀治疗慢性特发性荨麻疹 88例 ,观察治疗效果和不良反应。 方法 应用随机开放平行对照的方法 ,对 166例慢性特发性荨麻疹进行临床观察。患者随机分成两组 ,88例接受咪唑斯汀治疗 ,78例接受西替利嗪治疗 ,疗程 2 8d。用症状积分下降指数判定疗效 ,通过复诊观察不良反应。 结果 咪唑斯汀治疗慢性特发性荨麻疹的显效率为 85 % ,88.6%明显高于西替利嗪 ( 73% )。治疗过程中除口干、嗜睡、乏力、恶心外 ,无明显不良反应。 结论 咪唑斯汀是一种新的第二代抗组胺药物 ,它起效快 ,持续时间长 。

Objective To observe the therapeutical effect and adverse reactions to mizolastine in patients with chronic idiopathic urticaria. Methods 166 chronic idiopathic urticaria patients were divided randomly into two groups.88 cases were treated with mizolastine and 78 cases were treated with cetirizine as the control group.the clinical response was analysed by the decrease index of symptom integral 28 days after treatment. Results The total effective rate in mizolastine group was 88.6%,significantly higher than cetirizine group (73%).The adverse effects of Mizolastine therapy were minimal except for few cases with thristy,sleepy,faint,nausea. Conclusion Mizolastine as a new second generation anti-histamine medicine is effective and safe on urticaria.