泌尿生殖道支原体感染状况及药敏动态分析

Dynamic analysis of the infectious status and drug resistance of chlamydia in the urogenital tract

目的 了解泌尿生殖道感染患者支原体的感染情况及对药物的敏感性。 方法 应用生物 -梅里埃My coplasmaIST试剂盒进行检测及分析。 结果 165 9例患者的支原体培养 ,阳性 766例 ( 46.2 % ) ,其中解脲支原体(UU)阳性 738例 ( 44.5 % )人形支原体 (Mh)阳性 14 1例 ( 8.5 % )。UU +Mh阳性 113例 ( 6.8% )。男、女患者的阳性率分别为 2 7.0 %和 5 2 .2 % ,经统计学处理 ,差异有显著性 (x2 =77.5 7,P <0 .0 1)。支原体敏感的药物分别是原始霉素 ( 83.8% )、交沙霉素 ( 70 .4% )、强力霉素 ( 64.8% ) ,耐药率最高的是红霉素 ( 5 5 .5 % )、四环素 ( 39.7% )。近 4年来药敏率有所回升 ( 10 % )。 结论 应更加重视女性患者支原体感染的防治 ,治疗宜首选交沙霉素 。

Objective To understand the mycoplasma infection and antimicrobial susceptibility from the urogenital samples of urogenital tract infection patients. Methods Mycoplasma IST kits were used. Results 766 out of the 1659 cases showed mycoplasma positive (46.2%).Ureoplasma Uralyliam(uu) positive were 738 cases (positive rate 44.5%).Mycoplasma hominis (Mh) positive were 141 cases (positive rate 8.5%) and Mixed infection of both UU and Mh were 113 cases (positive rats 6.8%).The female positive rate was 52.2% and the male 27.0%(x 2=77.57,P<0.01).The positive rate of famale was higher than that of male.There was no difference from venereology department and obstetrics department about the positive rate.The sentistive antibiotics were pristinamycin(83.8%),josamycin(70.4%) and Doxcycline(64.8%).The resistance rates of the tested mycoplasma against erythromycin and tetracycline were 55.5% and 39.7%.From 1998 to 2000,the antibiatics sentistive rates became higher (about 10%). Conclusion We should pay more attention to femal infection of Mycoplasma,and josamycin and doxycycline may be selected as the first drugs to treat mycoplasma infectction.