趋化因子与口腔疾病

Relationship between chemokine and oral disease

趋化因子 (chemokine)是一组 70～ 90个氨基酸组成的小分子量 (Mr 8× 1 0 3～ 1 0× 1 0 3)蛋白质 ,它们具有 4个保守的半胱氨酸 (cysteine,c)残基。趋化因子能特异地趋化白细胞 ,还参与免疫、造血及血管形成过程 ,与某些器官的发育也有关系。口腔中多种组织和细胞 ,如牙龈上皮细胞、牙龈成纤维细胞、成牙本质细胞、牙髓成纤维细胞、口腔黏膜细胞等都能表达和分泌多种趋化因子。趋化因子通过趋化激活白细胞、促进血管生长等作用方式参与口腔组织的多种疾病 ,如牙髓炎、牙周炎。

Chemokines are a superfamily of proteins wit h low molecular weight (Mr 8×10 3～10×10 3),composed of 70～90 amino acids , and have 4 conservative cysteine residues.Chemokines can selectively attract a nd activate leukocytes and a variety of other types of cells. Chemokines still p lay a role in the process of immunity? angiogenesis?hematopoiesis and developm ent of some organs. In oral tissues, there are many kinds of cells,such as gingi val epithelium ?gingival fibroblasts?pulp fibroblasts?odontoblasts?oral m ucosal cells.All of them can express and secret chemokines. By attracting and ac tivating leukocytes, stimulating angiogenesis, and another ways, chemokines can act in many oral diseases, which include pulpitis,periodontitis,lichen planus ,and so on.