利培酮治疗儿童精神分裂症对照研究

A study of risperidone in the treatment of child schizophrenia

目的 :比较利培酮和氟哌啶醇治疗儿童精神分裂症的疗效和不良反应。 方法 :4 2例儿童精神分裂症患者随机分为利培酮组和氟哌啶醇组 ,治疗 6周。用简明精神病评定量表 (BPRS)和副反应量表 (TESS)评定疗效和不良反应。 结果 :利培酮组和氟哌啶醇组BPRS总分在治疗末均显著下降 ,两组间BPRS总分差异无显著性 ;两组间疗效差异亦无显著性 ;利培酮组不良反应发生率比氟哌啶醇组明显为低。 结论 :利培酮治疗儿童精神分裂症安全有效 。

Objective:To compare the therapeutic and side effects of risperidone and haloperidol in the treatment of child schizophrenia. Method:Forty two cases of child schizophrenia patients were randomized into two groups and were treated for six weeks with risperidone and haloperidol respectively.Symptom improvement and side effects were rated with clinical evaluation,BPRS and TESS. Results:Both groups showed signifcant decline in the total scores of BPRS at the end of the treatment while there is no signifcant difference between the two groups either in BPRS or in clinical evaluation.Risperidone group reported significantly less side effect than haloperodol group. Conclusion:Risperidone is effective and safe in the treatment of child schizophrenia and can be considered as the first choice for this treatment.