Pharmacokinetics of intraperitoneal chemotherapy with continuous washing methods for patients with ovarian cancer

Objective: To compare the pharmacokinetics of the routine intraperitonealchemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin(CDDP) in 38 patients with ovarian cancer. Methods: The patients had a performance status ofⅡ -Ⅳ on the FIGO scale.38 patients were randomized into CWIP group (16 patients) and RIP group(22 patients). CDDP was used as intraperitoneal chemotherapy (IP) with 70mg/m2. In 72h, thesamples from serum, ascites and urine were collected respectively and their platinum density weredetermined with electrochemistry polarographic analysis. On the third day and one month after IP,liver and kidney function and blood routine were examined. Results: The maximum concentration(Cmax) of plasma in CWIP and RIP groups were 3.84μg/ml and 1.27μg/ml respectively;the Cmaxof ascites were 7.04μg/ml and 4.43μg/ml respectively in the two groups. The area under the plas-ma concentration-time curve(AUC) in CWIP and RIP groups were 1067.77μg. h/ml and 191.72μg.h/ml respectively,and 1299.02μg. h/ml and 584.43μg. h/ml in ascites,their statistics dif-ference were significant ( P ＜ 0.05). Conclusion: CWIP is better than the RIP in the pharmacoki-netics, while its side-effects is not increased. The new methods may be used on the patients.

Objective: To compare the pharmacokinetics of the routine intraperitoneal chemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin (CDDP) in 38 patients with ovarian cancer.Methods:The patients had a performance status of II -IV on the FIGO scale.38 patients were randomized into CWIP group (16 patients) and RIP group (22 patients). CDDP was used as intraperitoneal chemotherapy (IP) with 70mg/m2. In 72h, the samples from serum, ascites and urine were collected respectively and their platinum density were determined with electrochemistry polarographic analysis. On the third day and one month after IP, liver and kidney function and blood routine were examined. Results: The maximum concentration (Omax) of plasma in CWIP and RIP groups were 3.84μg/ml and 1.27μg/ml respectively; the Cmax of ascites were 7.04μg/ml and 4.43μg/ml respectively in the two groups.The area under the plasma concentration-time curve(AUC) in CWIP and RIP groups were 1067.77μg/ml and 191. 72μg.h/ml respectively,and 1299.02μh/ml and 584.43μ@g. h/ml in ascites, their statistics difference were significant (P <0.05) .Conclusion:CWIP is better than the REP in the pharmacokinetics, while its side-effects is not increased.The new methods may be used on the patients.