左氧氟沙星治疗急性下呼吸道细菌感染的疗效观察

Treatment of Acute Lower Respiratory Tract Bacterial Infection by Levofloxacin in Sequential Therapy

目的 评价左氧氟沙星序贯疗法治疗急性下呼吸道细菌感染的疗效和安全性。方法 对 38例急性下呼吸道细菌感染患者 ,采用左氧氟沙星 0 .3～ 0 .6 g/d ,6～ 8d静脉滴注 ,继之以 0 .2 ,bid ,4～ 7d ,po。 结果 痊愈11例 ( 2 8.95 %) ,显效 2 4例 ( 6 0 .5 %) ,有效率 92 .11%,细菌消除率 92 .86 %,总疗程 10～ 15d(平均 11.6d) ,药物副作用较少 (发生率 2 .6 3%)。结论 左氧氟沙星序贯疗法治疗急性下呼吸道常见细菌性感染有效、安全。

OBJECTIVE To evaluate the efficacy and safety of levofloxacin in treatment of acute lower respiratory tract bacterial infection (ALRTBI) by sequential therapy. METHODS Thirty eight patients with ALRTBI were treated with levofloxacin iv drip in a regimen of 0.3-0.6 g/d for 6-8d then with oral levofloxacin in dose of 0.4 g/d for 4-7d in sequence. RESULTS An effective rate of 92.11% and a bacterial eradication rate of 92.86% were obtained with a tolerable side effect of 2.63%.CONCLUSIONS Levofloxacin in sequential therapy is an effective and safe agent for treatment of ALRTBI.