摘要
目的 探讨氨基胍 (AG)对脑缺血 再灌注 (IR)神经细胞损伤的影响。方法 用线栓法制作大鼠局灶性脑缺血 再灌注模型 ,动物缺血 2小时后给予腹腔注射AG 10 0mg·kg-1,取不同再灌注时间测定大鼠脑匀浆NOS活性、髓过氧化物酶 (MPO)活性和脑梗死体积。结果 再灌注后 12～ 72小时 ,AG显著降低了iNOS活性 ,且于再灌注后 2 4小时达最大抑制率。再灌注后 2 4～ 72小时 ,AG减少髓过氧化物酶 (MPO)含量。再灌注后 2 4～ 72小时 ,AG减少梗死体积。结论 AG对脑缺血 再灌注神经细胞损伤具有一定的保护作用。
Objective To investigate the effect of aminoguanidine on the neuronal injury following cerebral ischemia and reperfusion in rats.Methods Rats were injected AG 100 mg·kg -1 following cerebral ischemia and reperfusion and were assessed the activity of NOS, the amount of MPO and the infarct size at different time.Results AG could decrease significantly the activity of NOS, the amount of MPO and the infarct size.Conclusions AG can protect neurons from cerebral ischemia and reperfusion.
出处
《卒中与神经疾病》
2003年第2期75-77,共3页
Stroke and Nervous Diseases
