肌萎缩性侧索硬化症患者体感诱发电位研究

A study on somatosensory evoked potentials in patients with amyotrophic lateral sclerosis

目的 研究肌萎缩性侧索硬化症 (ALS)患者体感诱发电位 (SEP)变化。方法 采用正中神经及胫后神经体感诱发电位 (mSEP、tSEP)对 30例患者进行检测 ,并与 2 7例健康人作对比。结果 mSEP和tSEP的异常率分别为 43 .3%( 13/ 30 )及 2 8%( 7/ 2 5 ) ,除N9、PF(点 )、LP(T12 点 )峰潜伏期和对照组相比无显著差异外 ,其余各峰潜伏期及峰间期和对照组相比均有显著性差异。结论 ALS患者存在感觉通路损害 ,且中枢的改变较周围更明显 ,SEP检查对患者感觉损害的定位有一定价值。

Objective To observe the changes of somatosensory evoked potentials (SEP) in the patients with amyotrophic lateral sclerosis (ALS).Methods 30 patients with ALS were analysed with median nerve somatosensory evoked potentials (mSEP) and tibial nerve somatosensory evoked patentials (tSEP) and compared with 27 healthy persons.Results mSEP and tSEP were abnomal in 13( 43.3%) of 30 and 7(28%) of 25 tested patients. The mean values of SEP peak latencies and interpeak latencies except peak latencies (N 9, PF and LP) increased in ALS patients compared with controls. Conclusions The results of our study suggest that the damage of sensory pathways exist in ALS. Central abnormalities of SEP were more obvious than peripheral abnormalities. SEP examination had some value in localization of sensory lesion in ALS patients.