清淋冲剂的主要药效学研究

Studies on main pharmacodynamic of Qinglin Granules

目的 :观察清淋冲剂 (蓄、瞿麦、关木通、车前子 ,栀子等 )的解热、利尿、抗炎和抗菌作用。方法 :采用鲜酵母致热大鼠法、利尿试验、蛋清致大鼠足跖肿胀法、二甲苯致小鼠耳廓肿胀法、纸片扩散法 ,观察清淋冲剂对动物体温、尿量、足肿胀程度、耳廓肿胀程度及体外抑菌情况。结果 :给药后大鼠体温显著下降 ,尿量显著增加 ,大鼠足跖肿胀和小鼠耳廓肿胀显著减轻 ,大肠杆菌、绿脓杆菌、变形杆菌、产气杆菌、淋球菌及金黄色葡萄球菌抑菌环显著增大。结论 :清淋冲剂具有明显的清热、利尿、抗炎作用 。

Objective: To observe antipyretic, diuresis, anti inflammatory and antisepsis effects of Qinglin Granules. (Herba Polygoni Avicularis, Herba Dianthi, Caulis Aristolochiae Manshuriensis, Semen Plantaginis, Fructus Gardeniae, etc.) Methods: The model of pyretic rats induced by yeast was used to prove antipyretic action. The diuresis action was observed by the test. The anti inflammatory effect was observed by pettitoes swelling in rats and auricle swelling in mice. The paper diffuse methods were used to confirm the antisepsis effect. Results: Qinglin Granules not only had the obvious effect of relieving fever and increasing the amount of urine, but also had the strong inhibition on the two kinds of inflammatory models, moreover it can widen the diameter of the antisepsis ring which showed it had the inhibition on cdibacillus, pseudomonas, aeruginosa, bacillus gasoformans, staphylococcus aureus and gonococcic. Conclusion: Qinglin Granules have the obvious antipyretic, diuresis, anti inflammatory and antisepsis effects.