母体不同孕期与新生儿血中瘦素水平的观察

Investigation of Serum Leptin Levels in Pregnant Women DuringVarious Trimesters and Their Neonates

目的 :观察母体在不同孕期血清与新生儿脐血中瘦素水平变化及其相关关系。方法 :应用放射免疫分析 ,随机对 3 0 0例孕前、孕早期、孕中期和临产时母体血清及新生儿脐血中的瘦素水平进行了检测。结果 :妇女孕早期与孕前血中瘦素之间变化基本一致 (p >0 0 5 ) ,从孕中期开始血清瘦素水平则明显升高 ,分娩时达到高峰 (p <0 0 5或p <0 0 1)。新生儿脐血中瘦素水平与孕前母体血中瘦素水平较为一致。妇女妊娠前、后血清瘦素水平均与体重、体重指数、腹围、子宫底高度、舒张压、收缩压呈正相关。新生儿脐血瘦素水平与出生体重呈正相关 ;而与其母体瘦素水平呈负相关。结论 :新生儿瘦素来自自身 ,其浓度主要由脂肪组织的积累程度决定。检测孕期母血中瘦素浓度对判断、预测胎儿体重帮助意义不大 ,但可以了解母体孕期体重增加程度 。

Objective To investigate the variations of serum leptin levels in pregnant women of various trimesters and their neonates as well as the correlativity in between. Methods Serum leptin levels in 300 women at pregestation during the three trimesters and the umbilical blood leptin levels in their neonates were measured with RIA. Results Serum leptin levels in pregnant women rose significantly only from midegestation with a peak at partum ( p <0 05 or p <0 01 vs pregestation). The leptin levels in neonates were almost the same as those of women of pregestation. The maternal leptin levels were positively correlated to body weight, body weight-index, abdominal perimeter, height of fundus of uterus, diastolic and systolic pressure. The leptin levels in neonates were positively correlated to the brith weight, but not correlated to maternal leptin levels. Conclusion Leptin in neonates comes from neonates themselves, and its concentrations are determined by the degree of accumulation of body adiposetissue. Measurement of blood leptin concentrations in pregnant women druing pregnancy has liffle meaning for accessing the body weight of fetus, but it can show the degree of maternal weight-gaining and may have some value for clinical observation of the syndrome of pregnant hypertenison.