测定醛固酮浓度/肾素活性(SAC/PRA)值在原发性醛固酮增多症中的临床意义

Clinial Significance of Determination of SAC/PRA Value in Patientswith Primary Aldosteronism

目的 :探讨测定SAC/PRA值对原发性醛固酮增多症的诊断价值。方法 :采用放射免疫分析法测定 4 8例原发性醛固酮增多症患者和 3 0例正常人的血浆肾素 (PRA) ,血管紧张素Ⅱ (AT -Ⅱ )以及血清醛固酮(Aldo) ,并计算醛固酮浓度 /肾素活性 (SAC/PRA)比值。结果 :正常组PRA、AT -Ⅱ、Aldo测定值分别为 0 5 7±0 0 8ng/ml/h ,3 6 0 3± 6 11ng/L ,0 3 3± 0 0 4nmol/L ;原醛患者PRA、AT -Ⅱ、Aldo测定值分别为 0 14± 0 0 8ng/ml/h ,2 1 2 1± 7 5 5ng/L ,1 0 7± 0 3 4nmol/L。与正常对照组比较 ,均有极显著性差异 (p <0 0 0 1)。SAC/PRA(ng/dl/ng·ml-1·h-1) 913± 4 0 9。结论

Objective To investigate the diagnostic significance of determining SAC/PRA valve in byperaldosteronism. Methods Plasma renin activity (PRA) and angiotensin (AT-Ⅱ) as well as serum aldosterone contents were measured with RIA in 48 patients with primary aldosteronism and 30 controls. The SAC/PRA value was calculated. Results Contents of PRA, AT-Ⅱ and Aldo in blood of patients with primany aldosteronism were very significantly different from those in controls ( p <0 001) (PRA 0 14±0 08ng/ml/h vs 0 57±0 08ng/ml/h; AT-Ⅱ 21 21±7 55ng/L vs 36 03±6 11ng/L; Aldo 1 07±0 34nmol/L vs 0 33±0 04nmol/L). Calculated SAC/PRA value was 913±409(normal upper limit 400). Conclusion SAC/PRA value is an useful accessory diagnostic criterion for primary aldosteronism.