内分泌干扰物诱导睾丸生精细胞凋亡的研究进展

The Involvement of Endocrine Disrupting Chemicals in Spermatogenic Cell Apoptosis

睾丸生精细胞存在着自发性和化学物质诱发性凋亡。现代工业造成大量污染物涌入环境中 ,而这其中许多物质被证实具有生殖毒性 ,能够影响机体的生殖和发育。这类污染物被归属为内分泌干扰物 (EDCs EDs)。研究EDCs所诱导的生精细胞凋亡将丰富和拓展其甄别的依据及其途径 ,并对作用机制提出新的阐述 ,在生殖毒理学领域。

Elimination of spermatogenic cells via apoptosis occurs spontaneously under normal physiologic conditions and is often aggravated after chemical induced testicular impairment. A great amount of pollutants is released into the environment by modern industry, and many of these substances have been confirmed possessing reproductive toxicity, which can affect the reproduction and development of organism. These chemicals have been categorized to endocrine disrupting chemicals(EDCs). Studying spermatogenic cell apoptosis induced by EDCs will enrich and expand the pathway to identify EDCs, and will put forward new expounding of its mechanism. It has important meaning in the field of reproduction toxicology and male fertility.