体外反搏对血管性痴呆患者P300的影响

Effect on event related potential-P300of patients of the vascular dementia by external conut erpulsation

目的采用事件相关电位P300指标作为反映脑血管疾病患者认知功能障碍客观生理指标,并通过体外反搏治疗前后观察患者P300变化情况。方法应用美国NicoleSpirit脑诱发电位仪,通过“听觉靶…非靶刺激序列”为诱发事件,记录正常老人组48例,脑血管疾病组28例,及体外反搏组20例,并进行统计分析。结果正常老人组与脑血管疾病组事件相关电位P300全部指标都有明显差异。体外反搏治疗前后比较,靶潜伏期N2、P3有较明显差异,非靶刺激C2区P3也同样有明显差异,其它指标不同程度好转,但无差异。结论P300指标为临床早期诊断血管性痴呆提供了可靠依据。体外反搏能明显增加脑部血液供应,同时可以预防缺血性脑血管痴呆发生和发展。体外反搏为临床早期治疗血管性痴呆提供行之有效方法。

Aim To observe changes of event related p otential-P300(ERP)and it will become indication that decides obstacle of recognition function with cerebral vascular dis eases.Methods The normal old age 48,cerebral vascular diseases 28and external counterpulsation(ECP)treatment group 20of event related potential-P300were recorded with a serial of stimulation targe and nontarget by Nicole Spirit of USA.All information was analyzed by statistics of SPSS 7.5.Results All indication was difference evidently in event related potentia l-P300with compared normal old age a nd cerebral vascular diseases.After t reatment by ECP,P300waves were in-creased and latencies were shortened than before treatment in20.Conclusion The early vascular dementia may be di agnosed by P300and provide scientific basis for cli nical study.The external counterpulsation not only can improve cerebral circul ation but also prevente occurring an d developing for early vascular demen tia.