精神分裂症发病年龄与家族遗传的相关性分析

A correlative analysis of the inheritance and the attack age in schizophrenia

目的 探讨精神分裂症住院患者的发病年龄、家族遗传及其相互关系。方法 对 2 0 0 2年 1月 1日在院的精神分裂症患者 2 2 0例的发病年龄及其家族遗传情况进行回顾性研究。结果 ①精神分裂症男性患者平均发病年龄为 (2 6 75± 7 85 )岁 ,女性为 (2 6 14± 7 97)岁 ;t=0 5 6 2 2 ,P =0 5 74 7。②家族史阳性患者的平均发病年龄为(2 6 84± 9 16 )岁 ,阴性患者为 (2 6 2 3± 7 2 7)岁 ;t=0 4 94 7,P =0 6 2 2 2。③男性精神分裂症患者家族遗传史阳性占 2 4 5 1% ,女性占 37 2 9% ;χ2 =4 15 ,P <0 0 5。结论 ①精神分裂症发病年龄无性别差异。②家族遗传因素对精神分裂症的发病年龄无直接影响。③女性患者起病似乎更易受家族遗传因素影响 。

Objective To explore the correlation of the inheritance and the attack age in schizophrenia.Methods 220 patients with schizophrenia were studied by the attack age and inheritance in hospital.Results ① the mean attack age was (26 75±7 85) years in male patients and was (26.14±7.97) years in female patients.There was none significant difference on attack age between male and female in schizophrenia( t =0.5622, P =0 5747).② The mean attack age was(26.84±9.16) years in positive inheritance patients and was (26.23±7.27) years in negative inheritance patients.There was none significant difference on attack age between the negative and positive inheritance patients in schizophrenia( t =0.4947, P =0.6222).③ There are high rate of inheritance in female(37.29%) than in male ( 24.51 %) in schizophrenia (χ 2=4.15, P <0.05).Conclusion There are none sexuality difference and inheritable influence on attack age in schizophrenia,the results also shows it maybe have sex-linked inheritance in schizophrenia.