大肠癌组织中CD_944v6)和PCNA表达及其临床生物学意义

EXPRESSION OF CD_(44v6) ,PCNA IN COLORECTAL CANCER AND ITS CLINICOBIOLOGICAL SIGNIFICANCE IN PATIENTS WITH COLORECTAL CANCER

目的 :探讨 CD4 4v6 和细胞核增生抗原 (PCNA)在结直肠癌组织中的表达情况与临床病理关系。方法 :采用 ABC和 SP免疫组化方法检测 84例结直肠癌组织中的 CD4 4v6 和 PCNA的表达情况 ,用统计学 χ2检验分析 CD4 4v6 和 PCNA的表达意义。结果 :CD4 4v6 和 PCNA在大肠癌组织中的表达具有一致性 ,与癌肿的浸润深度及淋巴转移、Dukes′分期呈正相关 ,与年龄、性别及组织学类型无关。结论 :结直肠癌组织中 CD4 4v6 和 PCNA呈高表达是预后差的生物学指标 ,而高增生状态的癌细胞对化疗敏感 ,故对 CD4 4v6 和 PCNA呈高表达患者予严格的术后化疗 ,可望提高疗效。

Objective:To explore the expression of CD 44v6 , PCNA in colorectal cancer and its clinicopathological significance.Methods:CD 44v6 and PCNA were immunohisto chemically studied by ABC and Sp in the 84 colorectal cancers.Statistic method was used to analyse the relationship between CD 44v6 , PCNA and clinicopathological manifestation.Results:CD 44v6 ,PCNA distributed in both colorectal cancer tissue and non colorectal cancer,but there was a significant difference between them,and there was no significant correlation with some clincopathological parameters,such as age,sex and differentiation.There was a close relationship with other clinicopathological para meters ,such as invasion depth ,metastasis to regional lymph node,and Dukes stages.Conclusion:The strong expression of CD 44v6 ,PCNA in colorectal cancer would be biologic markers of worse prognosis, but strong PCNA would be a biologic markers of cancer cell in high growth status,which susceptible to 5 Fu ,and adjuvant chemotherapy for the patients may improve the result of radical resection.