闭经溢乳综合征(附25例分析)

GALACTORRHEA-AMENORRHEA SYNDROMES (ANALYSIS OF 25 CASES)

25例闭经溢乳综合征中垂体腺瘤7例,年龄24～42岁。全组均有溢乳,自觉溢乳者12例,病程1.39±0.72年,最长者8年。检查发现溢乳13例。25例均为继发闭经,病程6月～8年,平均2.88±2.38年。诊断除病史查体外,重点辅以催乳素、雌二醇的放射免疫测定及CT扫描。垂体腺瘤采取手术加放疗或溴隐亭,其余均用溴隐亭。21例停止溢乳、月经恢复,其中排卵月经14例。23例已婚者中8例妊娠。

Twenty-five cases of galactorrhea-amenorrhea syndromes, including 7 with pituitary adenoma, were reported in this paper. The age of patients ranged from 24 to 42 years. All the patients displayed galactorrhea. In 12 cases, galactorrhea occurred spontaneously. The onset of the symptom was in 1.39±0.72 years, longest one in 3 years. In 13 cases, galactorrhea was noted following manual expression. All cases presented with secondary amenorrhea. Thduration was 6-8 years ( mean 2.88±2.38 years). The diagnosis of galactorrhea-amenorrhea syndromes was made by measuring serum prolactin and estradiol by radioimmunoassay(RIA)and computerized tomography (CT) scan besides history and examination.Surgical therapy, radiopraxis or bromocriptine therapy were recommended for patients with pituitary tumor. The others were treated with bromocriptine therapy. As a result, 21 cases stopped galactorrhea, resumed menstruation and established ovulatory cycles. The 8 pregnancies were observed in 23 married women.