摘要
尼群地平是一种新型的钙拮抗剂,临床上用于治疗高血压。在碱性条件下用乙醚/环己烷(3/7)混合溶剂从血浆中提取尼群地平,在气相色谱上直接进样(OV—17柱,电子捕获检测器)。在3—30ng/ml浓度范围内,标准曲线呈线性。对家兔的药代动力学参数一并报道。
Nitreadipine, a calcium antagonist, now widely used in the treatment of hypertension, was extracted from plasma under basic conditions with ether/hexane solvent (3/7). An aliquot of the extract is injected directly into a gas chromatography equipped with OV-17 column and an electon capture detector. The standard curve is linear between 3-30ng/ml. Pharmacokinetic parameters obtained in the intravenous administration of four rabbits are reported.
关键词
尼群地平
气相色谱
药代动力学
Nitrendipine
gas chromatography, pharmacokinetic parameter
