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白血病抑制因子及其受体与妊娠 被引量：1

Leukemia Inhibitory Factor and It's Receptor with Pregnancy
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摘要 白血病抑制因子 ( LIF)是一种多生物学活性的细胞因子。近年来的研究表明 ,LIF存在于子宫内膜、妊娠期蜕膜及胎盘上。它通过与其受体 ( LIFR)结合 ,从而调节胚胎的着床及妊娠的维持。LIF不仅与其他细胞因子之间相互调节 ,且它还受到激素内分泌的严格调控。进一步研究还发现 ,原因不明不孕症妇女子宫内膜 LIF的表达较正常妇女减弱甚至缺失 ,这提示 LIF的异常表达可能是原因不明不孕症患者着床失败的原因之一 。 Leukemia inhibitory factor (LIF) is a cytokine with various biological activities. Recent researches show that it is expressed in endometrium, deciduas and placenta. Through binding with its receptor, it can regulate the embryo implantation and maintain pregnancy. Besides the mutual regulation between LIF and other cytokines, it is also strictly regulated by hormones. Further research shows that LIF was defectively expressed in the endometrium of women with unexplained infertility than that in normal women, which not only indicates that LIF maybe the reason for the fail of implantation, but also highlights a new way to treat the unexplained infertility.
作者 张松灵 杨玉兰 王丽娜 刘虹晶
机构地区 吉林大学第一医院妇产科
出处 《生殖与避孕》 CAS CSCD 北大核心 2003年第2期118-122,共5页 Reproduction and Contraception
关键词 白血病抑制因子(LIF) 白血病抑制因子受体(LIFR) 着床 不孕症 LIF, LIF receptor, implantation, infertility
分类号 R321 [医药卫生—人体解剖和组织胚胎学]
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参考文献26

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同被引文献16

  • 1郭艺红,孙莹璞,乔玉环,苏迎春,陈秋菊,陈爱军,刘新贵.多囊卵巢综合征患者卵泡液LIF、IL-1β及性激素水平与IVF-ET结局关系的研究[J].生殖与避孕,2004,24(6):344-348. 被引量：8
  • 2Arici A, Oral E, Bahtigar O, et al. Leukemia inhibitory factorin human follicular fluid and ovarian cells. Hum Reprod, 1997, 12(6):1 233-9.
  • 3Schofield G, Kimber SJ. Leukocyte Subpopulations in the Uteri of Leukemia inhibitory factor knockout mice during early pregnancy. Biol Reprod, 2005, 72(4):872-8.
  • 4Hambartsoumian E. Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation. Am J Reprod Immunol, 1998, 39(2): 137-43.
  • 5Sharkey A. Cytokines and implantation. Rev Reprod, 1998, 3(1):52-61.
  • 6Hilton D J, Gough NM. Leukaemia inhibitory factor: a biological perspective. Cell Biochem, 1991,46(2):21-6.
  • 7Brannstrom M, Pascoe V, Norman R J, et al. Localization of leukocyte subsets in the follicle wall and in the corpus luteum throughout the human menstrual cycle. Fertil Steril, 1994, 61(3):488-95.
  • 8Zhao Y, Niehols JE, Bulun SE, et al. Aromatase P450 gene expression inhuman adipose tissue. Role of Jak/STAT pathway inregulation of the adipose-specific promoter. J Biol Chem, 1995,270(27): 16 449-57.
  • 9Sawai K, Matsuzaki NV, Okada T, et al. Human decidual cell biosynthesis of leukaemia Inhiti-bory factorvv: regulation by decidual cytokinesand steroid hormones. Biol Reprod, 1997, 56(5):1 274-80.
  • 10Dlugi AM, Laufer N, DecherneyAH, et al. The priovulatory and luteal phase of conception cycles following IVF and ET. Fertil Steril, 1984, 41(4):530-7.

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生殖与避孕
2003年 第2期

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