功能性消化不良患者胃感觉运动功能的研究

Gastric sensorimotor function in patients with functional dyspepsia

目的 探讨胃感觉运动功能障碍在功能性消化不良 (FD)患者中的表现和相互关系。方法 用单光子放射计算机断层成像 (SPECT)和内脏刺激器 /电子气压泵检测 2 2例FD患者和 2 0例健康对照者的胃固体排空、胃敏感性、胃顺应性和近端胃容受性。结果 2 2例FD患者胃排空延迟、胃敏感性增高和近端胃容受性障碍的发生率分别为 31.8% ,6 8.2 %和 4 5 .5 % ,其中 4 5 .5 %的患者出现了两种以上的胃感觉运动功能障碍。三种胃感觉运动功能障碍间无相关关系 (P >0 .0 5 )。结论 胃排空延迟、胃敏感性增高及近端胃容受性障碍是FD发病中三种相互独立的重要因素 ,不同的病理生理异常可在同一FD患者中共存。

Objective To investigate the aspects of gastric sensorimotor function and their inter relationships in patients with functional dyspepsia(FD). Methods A gastric barostat and single photon emission computerized tomography(SPECT) were used to study gastric sensitivity, gastric compliance, proximal gastric accommodation and gastric solid emptying respectively in 22 patients with FD and 20 healthy control subjects. Results Among the 22 patients with FD, the incidence rates of gastric hypersensitivity, impaired proximal gastric accommodation and delayed gastric emptying were 68.2%, 45.5% and 31.8% respectively. 45.5% patients with FD had more than two aspects of gastric sensorimotor dysfunction at the same time. There was no correlation among gastric hypersensitivity, impaired proximal gastric accommodation and delayed gastric emptying ( P >0.05). Conclusions Gastric hypersensitivity, impaired proximal gastric accommodation and delayed gastric emptying may be important but independent pathophysiological factors of FD. Different pathophysiological factors can coexist in one patient with FD.