氨氯地平对老年收缩期高血压患者大动脉内皮功能和粥样硬化的影响

Effects of Amlodipine on Endothelial Function and Atherosclerosis of Large Arteries in Elderly Isolated Systolic Hypertension Patients.

目的 评价氨氯地平对老年收缩期高血压 (EISH)患者大动脉内皮功能和粥样硬化的影响。方法 选择老年收缩期高血压患者 2 5例 ,应用高分辨超声技术检测EISH患者氨氯地平治疗 12周前后的肱动脉内皮依赖性舒张功能(FMD) ,颈动脉平均内中膜厚度 (MIMT)及颈动脉斑块的Crouse积分 ,并观察治疗前后收缩压和脉压的变化。结果 EISH患者治疗 12周后收缩压、脉压和MIMT比治疗前明显下降 (P <0 .0 5或 <0 .0 1) ,FMD明显改善 (P <0 .0 1)。结论 氨氯地平除能有效降低EISH患者的血压外 。

Objective To evaluate the effects of amlodipine on endothelial function and atherosclerosis of large arteries in elderly isolated systolic hypertension(EISH).Methods The brachialis arterial endothelium-dependent vasodilatalion (FMD) and carotid mean intimal-medial thickness(MIMT) and carotid plaques were measured in 25 patients with elderly isolated systotic hypertension before and afterr 12 weeks of the treatment with amlodipine by high-resolution ultrasound technique.In the meantime,systolic blood pressure and pulse pressure were measured before and after 12 weeks of the treatment.Results The systolic blood pressure,pulse pressure and MIMT were significantly decreased ( P <0.05-0.01),and FMD was markedly increased ( P <0.01) after 12 weeks treatment with amlodipine in EISH.Conclusions Amlodipine can not only control blood pressure,but also improve large arterial endothelial function in EISH patients.