骨膜蛋白与哮喘气道炎症相关性分析

Correlation analysis of periosteum protein and airway inflammation in asthma

目的分析支气管哮喘患者骨膜蛋白与气道炎症的关系。方法选择潍坊医学院附属医院就诊的70例哮喘患者为观察组,30例健康体检者为对照组。首先,对以上人群进行痰液诱导并处理痰液及痰液细胞分类、计数。其次,检测其血清中骨膜蛋白水平。结果与对照组比较,观察组患者血清骨膜蛋白明显升高(P<0.005),血清骨膜蛋白水平与诱导痰嗜酸性粒细胞百分比显著相关(r=0.357,P=0.002),与诱导痰中性粒细胞百分比无显著相关(r=0.032,P=0.759)。骨膜蛋白诊断哮喘界点24.5μg/L,此时其灵敏度为0.971,特异度为0.867。结论支气管哮喘患者血清骨膜蛋白的水平明显升高,血清骨膜蛋白水平可反映支气管哮喘患者嗜酸性粒细胞炎症即Th2型炎症,对于哮喘的诊断具有临床指导意义。

Objective To analyze the relationship between periosteal protein and airway inflammation in patients with bronchial asthma.Methods Seventy asthma patients treated in the Affiliated Hospital of Weifang Medical University were selected to form the observation group,and 30 healthy people were selected to form the control group.First,sputum induction and treatment of the above population sputum and sputum cell classification,counting.Secondly,serum levels of periostin were measured in the above populations.Results Compared with the control group,serum periosteum protein was significantly increased in the observation group(P<0.005),the observation group of patients serum periosteum protein levels and induced sputum eosinophil percentage into significant correlation(r=0.357,P=0.002),and induced sputum neutrophil percentage is no significant correlation(r=0.032,P=0.032).Periosteum protein in the diagnosis of asthma point 24.5μg/L,at this time the sensitivity of 0.971,the specificity of 0.867.Conclusion The levels of periosteum in the serum of asthmatic patients increased,periosteal protein level can reflect the eosinophilic inflammation in patients with bronchial asthma or Th2 inflammation,which is of clinical significance for the diagnosis of asthma.