皮肤淋巴细胞浸润症一例

Jessner's lymphocytic infiltration of the skin: a case report

患者,女,46岁。鼻根部肿胀性红斑2年,伴双眼睑水肿及双侧耳前皮下肿块20天。查体可见患者鼻背部及左侧下眼睑蚕豆大淡红色浸润性红斑,与周围正常皮肤界限不清,双侧耳前可触及花生大质硬椭圆形肿块。皮肤组织病理示(鼻根部):表皮轻度角化亢进,真皮层毛囊及皮脂腺周围可见较多淋巴细胞浸润。免疫组化染色显示:CD2(+),CD3(+),CD7(+),CD20(+),CD30(-),CD56(-),CD4(+),CD8(+),Ki67(10%+),EBER(-),提示浸润细胞以T淋巴细胞为主,伴少量B淋巴细胞。诊断:Jessner皮肤淋巴细胞浸润症。

A 46-year-old female presented with infiltrated erythematous plaques on the nasal root for 2 years and prominent swelling of the left eyelid and bilateral preauricular area for 20 days.Skin biopsy on the nose root revealed a dense lymphocytic infiltrate of dermis with perivascular and perifollicular distribution.Immunohistochemical analysis revealed CD2(+),CD3(+),CD7(+),CD20(+),CD30(-),CD56(-),CD4(+),CD8(+),Ki67(10%+),EBER(-),indicating that the infiltrate was predominantly composed of mature T lymphocytes and a few B lymphocytes.The diagnosis of Jessner’s lymphocytic infiltration was made.