重组人白细胞介素-11对化疗后血小板减少症的治疗作用

Therapeutic effects of domestic rhIL-11 on thrombocytopenia induced by chemotherapy

目的 :观察国产重组人细胞白介素 1 1(rhIL 1 1 )对化疗后病人血小板恢复的影响。方法 :45例实体瘤病人分为AB ,BA 2组进行自身交叉对照研究 ,A周期为化疗结束 2 4h开始 ,rhIL 1 1 2 5μg·kg-1,sc,qd× 1 4d;B周期为化疗结束后为空白对照 ,(2 8d为一个治疗周期 ) ;自化疗开始隔日查血常规 1次 ,观察各周期外周血小板计数变化。结果 :血小板最低值A周期值为 (1 1 8± 3 7)× 1 0 9·L-1,B周期为 (79± 2 8)× 1 0 9·L-1,差异有显著意义 ,P <0 .0 5 ;A周期外周血小板计数d 8后迅速回升 ,d 1 1恢复到化疗前值 ,B周期血小板计数d 1 4开始缓慢回升 ,始终低于A周期。结论 :rhIL 1 1可有效促进化疗后外周血小板恢复 ,缩短血小板减少持续时间 。

AIM: To evaluate the effect of domestic rhIL 11 on thrombocytopenia induced by chemotherapy. METHODS: Forty five patients with solid tumor were divided into group AB or BA by self control cross over test. At 24 h after chemotherapy, rhIL 11 was given 25 μg·kg -1 ·d -1 through subcutaneous injection from d 0 to d 14 in cycle A(1 chemotherapy cycle=28 days). In cycle B, the patients received chemotherapy alone without rhIL 11. Blood routine examination was taken every other day from the start of chemotheropy. The changes of peripheral platelet counts were observed. RESULTS: The lowest PLT is (118± s 37)×10 9·L -1 in cycle A, which is higher than (79±28)×10 9·L -1 in cycle B. There was a difference between the trial and control groups, P < 0.05. Peripheral platelet counts increased rapidly after d 8 in cycle A, but in cycle B, that increased slowly after d 14 and was lower than that in cycle A all the time. CONCLUSION: rhIL 11 plays an important role in accelerating the recovery of thrombocytopenia induced by chemotherapy. The patients are well tolerated.