夜来香根茎水提取液局部麻醉作用的研究

A Study of Local Anesthetic Effect of Cestrum Nocturnum Water Extract

目的 :研究夜来香 (CN)根茎水提取液的局部麻醉作用及其作用机制。方法 :采用蟾蜍离体坐骨神经动作电位法、豚鼠皮丘法、椎管麻醉法、表面麻醉法。结果 :2 0 %的CN水提取液对蟾蜍离体坐骨神经动作电位可完全消失 ,但较 1%的普鲁卡因稍弱。豚鼠皮丘实验表明 ,2 0 %CN提取液有浸润麻醉作用 ,其浸润麻醉效果与 1%的普鲁卡因相似 ,而且盐酸肾上腺素可增强其麻醉强度和明显延长局麻作用时间 ;家兔椎管麻醉实验表明CN提取液有明显的椎管麻醉作用 ;CN提取液对家兔角膜也有一定的表麻作用 ,只是作用强度及持续时间比 1%的普鲁卡因稍弱或稍短。结论

Objective:To study the local anesthetic effect of Cestrum Nocturnum.Methods:The conventional local anesthetic methods were used:(1)the method of the action potential of isolated sciatic nerve in toads;(2)themethod of infiltration anesthesia in guinea pig;(3)the method of intravertebral anesthesia in rabbits;(4) the method of superficial anesthesia in rabbits.Results:20% Cestrum Nocturnum(CN)can completely inhibit action potential of the isolated sciatic nerve in toads,but less than 1% hydrochloride procaine.It has effect of infiltration anesthesia similar to 1% procaine,and adrenalin hydrochloride can enhance its anesthetic intensity and obviously prolong the time of local anesthesia.It has effect of intravertebral anesthesia similar to 1% procaine too.It has also effect of superficial anesthesia,but less than 1% procaine.Conclusion: CN has local anesthetic effect.