肾动脉内注射L-精氨酸抑制肾神经传入纤维的自发活动(英文)

Intrarenal artery injection of L-arginine inhibits spontaneous activity of renal afferent nerve fibers

研究旨在应用记录肾传入神经多单位和单位放电的方法 ,观察肾动脉内注射L 精氨酸对麻醉家兔肾神经传入纤维自发放电活动的影响。结果表明 :( 1)肾动脉内注射L 精氨酸 ( 0 0 5、0 2 4和 0 48mmol/kg)可呈剂量依赖性地抑制肾传入纤维的活动 ,而动脉血压不变 ;( 2 )静脉内预先注射一氧化氮合酶抑制剂L NAME ( 0 11mmol/kg) ,可完全阻断L 精氨酸对肾传入纤维的抑制 ;( 3 )肾动脉注射一氧化氮 (NO)供体SIN 1( 3 .75 μmol/kg)也可抑制肾传入神经的活动。以上结果提示 :肾动脉内应用NO前体L 精氨酸和NO供体SIN

The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi- and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits. The results obtained are as follows: (1) intrarenal artery injection of L-arginine (0 05, 0 24, and 0 48 mmol/kg) decreased the renal afferent nerve activity ( ARNA) in a dose-dependent manner with arterial pressure unchanged; (2) pretreatment with a nitric oxide synthase inhibitor L-NAME (N6-nitro-L-arginine methylester, 0 11 mmol/kg), completely abolished the effect of L-arginine; and (3) intrarenal artery injection of a nitric oxide donor SIN-1 (3-morpholinosydnonimine, 3 75 μmol/kg) also resulted in an inhibition of ARNA. The results suggest that intrarenal artery injection of NO precursor (L-arginine) and donor (SIN-1) can inhibit ARNA in anesthetized rabbits.