期刊文献+

5α-还原酶在男性生殖中的作用 被引量:11

Roles of 5 α-reductase in male reproduction
下载PDF
导出
摘要 现已发现 5α-还原酶与男性的外生殖器发育、前列腺疾病发生及生精功能密切相关 ,并在中枢神经系统参与中枢性分化过程。睾酮 -5α-还原酶 -双氢睾酮 -雄激素受体系统作为一个整体在男性生殖中具有关键地位。本文综述 5α-还原酶近年来在男性第二性征、精子发生。
出处 《生殖医学杂志》 CAS 2003年第2期115-118,共4页 Journal of Reproductive Medicine
  • 相关文献

参考文献12

  • 1Vilchis F,Mendez JP,Canto P,et al.Identification of missense mutations in the SRD5A2 gene from patientswith steroid 5 alpha—reductase 2 deficiency[J].Clin Endocrinol(Oxf),2000,52(3):383—387.
  • 2Bird J,Li X,Lei ZM,et al.Luteinizing hormone and human chorionic gonadotropin decrease type 25 alphareductase and androgen receptor protein levels inwomen’S skin [J].J Clin Endocrinol Metab,1998,83(5):1776—1782.
  • 3Silver RI,Russell DW.5 alpha—reductase type 2 mutations are present in some boys with isolated hypospa—dias[J].J Urol,1999,162[3 Pt2]:1142—1145.
  • 4Poletti A,Martini L.Androgen—activating enzymes in the central nervous system[J].J Steroid Biochem Mol Biol,1999,69(1—6):117—122.
  • 5Poletti A,Negri—Cesi P,Rabuffetti M,et al.Transient expression of the 5 alpha—reductase type 2 isozyme in the rat brain in late fetal and early postnatallife[J].Endocrinology,1998,139(4):2171—2178.
  • 6Stoffel WB,Beyenburg S,Watzka M,et al.Expression of 5 alpha—reductase and 3 alpha—hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy[J].Epilepsia,2000,41(2):140-147.
  • 7Santner SJ,Albertson B,Zhang GY,et al.Comparative rates of androgen production and metabolism in Caucasian and Chinese subjects[J].J Clin Endocrinol Metab,1998,83(6):2104—2109.
  • 8Anderson RA,Kelly RW,Wu FCW.Comparison between testosterone enanthate—induced azoospermia and oligozoospermia in a male contraceptive study.V Localization of higher 5 alpha—reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone[J].J Andrology,1997,18(4):366—371.
  • 9Parte PP,Balasinor N,Gill—Sharma MK,et al.Effectof 5 alpha—dihydrotestosterone implants on the fertility of male rats treated with tamoxifen[J].J Andrology,2000,21(4):525—533.
  • 10O’Donnell L,Partis K,Stanton PG,et al.Testosterone—dependent restoration of spermatogenesis in adult rats is impaired by a 5α—reductase inhibitor[J].J Andrology,1999,20(1):109—117.

同被引文献68

引证文献11

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部