紫外分光光度法测定尼美舒利栓的含量

Determination of Nimesulide in suppositories by UV Spectrophotometry

目的 :建立用紫外分光光度法测定尼美舒利栓中尼美舒利的含量。方法 :用不同的有机溶剂萃取尼美舒利栓中的基质 ,用紫外分光光度法测定尼美舒利的含量。结果 :用正己烷作为萃取剂。用紫外分光光度法测定尼美舒利栓的含量 ,标准曲线线性好尼美舒利线性范围为 3～ 15 μg·ml-1(r =0 .9999)、回收率较好 (98.3% )。结论 :用紫外分光光度法测定尼美舒利栓剂的含量 ,方法简便、快速、结果准确 ,可作为尼美舒利含量测定的方法。

Objective: To establish a method for determination of nimesulide in suppositories. Methods: Screening different organic solution to extract the ground substrate in suppositories and determinating nimesulide by UV spectrophotometry. Results: N -Hexano was used as the solution of extraction. The method was very good for its good standard line( r = 0.9 999 ), high accuracy( RSD = 0.472% ) and high recovery( 98.3% ). Conclusion: This mehod is simple, rapid, and accurate.