活性蛋白C的临床应用进展

Clinical Application Progress ofActivated Protein C

活性蛋白 C( Activated protein C,APC)是一种内源性蛋白 ,具有抗凝血、促进纤维溶解、抗炎的功能。活性蛋白 C能够降低败血症患者的病死率 ( P =0 .0 5 ) ;降低血浆 D-二聚体的水平 ;血清白介素 6水平明显下降 ( P =0 .0 0 9)。2 0 0 1年 11月美国 FDA批准人类重组活性蛋白 C。

Objective: Activated protein C, an endogenous protein, has function of anticoagulant, promoting fibrinolysis and ant-inflammation. Activated protein C reduced the rate of death in patients with a clinical diagnosis of Septicemia (P=0.005). Plasma D-dimer levels were significantly lower in patients; Decreases in serum interleukin-6 levels were significantly greater in the patients (P=0.009). In November 2001, the Food and Drug Administration (FDA) approved recombinant human activated protein C for the treatment of patients with Septicemia whom have a high risk of death.