脑梗塞患者血浆内皮素和前列环素的研究

Plasma endothelin-1 (ET-1) and PGI_2 level in patients with cerebral infarction

目的:探讨内皮素—1(ET—1)和前列环素(PGI_2)在脑梗塞发病中的作用。方法:以放免分析法测定37例脑梗塞患者(研究组)和34例健康志愿者(对照组)的ET—1和PGI_2。结果:脑梗塞时ET—1水平明显升高,而PGI_2明显下降。结论:ET—1和PG2_2,均参与脑梗塞的病理生理过程,ET—1是一种致病因子,而PGI_2是一种保护因子,是ET—1的内源性拮抗剂。

Objective: To study the role of endothelin-1 (ET -1) and PGI2 in cerebral infarction. Methods: Plasma levels of ET -1 and PGI2were measured in 37 cerebral infarction. The measurement was performed 3 times at different stages of stroke. Results: There was a marked increase in plasma ET-1 level in the patients, while there was a marked decrease in plasma PGI2 level. Conclusion: ET - 1 and PGI2 play an important role in the regulation of the brain circulation. They seem to be involved in the pathophysiology, ET - 1 has a deleterious effect in the evolution of cerebral infarction and PGI2 has protection.