衣原体、支原体引起的难治性支气管肺部感染分析

Chlamydia and Mycoplasma Infections in Persistent Broncho-pulmonary Infections

目的 探讨难治性支气管 肺部感染 (难治组 )衣原体、支原体两种病原体的表达。方法 应用ELISA法检测了 2 9例难治性支气管 肺部感染两种非典型病原体急性感染指标 ,衣原体抗体IgM、支原体抗体IgM及冷凝集实验 ,并常规细菌学检查 ,与同期住院的普通性下呼吸道感染 (普通组 ) 4 0例 ,门诊及住院的急性上呼吸道感染 (上感组 ) 30例进行比较。结果 难治组衣原体急性感染率 6 8.9%,显著高于普通组、上感组 ,上感组最低 ;支原体急性感染率难治组 34 .5 %,显著高于普通组、上感组 ;衣原体混合支原体、衣原体混合其他致病菌感染均显著高于普通组和上感组。结论 难治性下呼吸道感染中衣原体、支原体感染率较高 ,且易与多种病原体混合感染 ,衣原体的慢性感染可能是难治感染的重要原因。

Objective To study the importance of detecting chlamydia and mycoplasma in persistent broncho-pulmonary infections.Methods 29 persistent broncho-plmonary infections(Group A),40 hospitalized common broncho-pulmonary infections(Group B),and 30 hospitalized patients with clinical diagnosis of upper respiratory infection(Group C) were sampled radomly for detection of chlamydia and mycoplasma.Cryoagglutination test was used to detect the bacteria and ELISA test was used to measure chlymydia and mycoplasma infection-specified serum IgM.Results The prevalence rate of acute chlamydia broncho-pulmonary infection was 68.9% in Group A, which was significantly higher than that in Group B or C,of which the prevalence rate in Group C was the lowest.The prevalence of chlamydia infection mixed with mycoplasma or accompanied with other pathogens was also significantly higher in Group A than that in Group B or Group C.Conclusion The prevalence of chlamydia infection is rather common in persistent broncho-pulmonary infections and the infection tends to be one mixed with mycoplasma and many other pathogens.