维思通与氟哌啶醇治疗阴性型精神分裂症

Treatment of Negative Symptoms of Schizophrenia byRisperidone and Halperidol

目的 评价维思通、氟哌啶醇治疗精神分裂症阴性症状的临床疗效。方法 研究对象为 72例符合CCMD -Ⅱ -R和DSM -Ⅳ精神分裂症诊断标准的住院患者 ,随机分为维思通组 37例 ,氟哌啶醇组 35例。采用前瞻性单盲对照研究方法 ,以阴性症状评定量表 (SANS)的得分结果来评价。结果 维思通治疗组在治疗前后SANS总分及各量表的综合评分均显著降低 (P <0 .0 5或 0 .0 1 )。结论 维思通对精神分裂症阴性症状的疗效显著优于氟哌啶醇 ,差异有显著性意义 (P <0 .0 1 )。

Objective To compare the theraputic effect of Risperidone and haloperidol on the negative symptoms of schizophrenia.Method this is a single-blind prospective study in which 72 schizophrenic patients with negative symptoms received Risperidol (n=37) and Haloperisol(n=35) respectively.The SANS,SAPS and HAMS were used for symptom evaluation.Results Risperodone reduced negative symptoms significantly reduced(P<0.05 or<0.01).The total SANS factors were more significantly ( P<0.01)  in Risperidone-treated subjects.Conclusion this is the first controlled study on the single-drug treatment of primary negative schizophrenic symptoms.Compared to conventional neuroleptic.haloperidol Risperidone's superior effect on negative symptoms may be related to its affinity to 5-HT receptors and possibly effects on other neuro-subsystems.