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中脑导水管周围灰质NO对大鼠血压的影响及其机制探讨 被引量：1

Study of Effect and Mechanism of Nitric Oxide in Midbrain Periaqueductal Gray on Blood Pressure in Rats
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摘要 目的探讨大鼠中脑导水管周围灰质 (PAG)NO对血压的影响及作用机制。方法采用微量注射法 ,观察大鼠血压的变化 ,放免法检测Ach含量。结果PAG内微量注射L NNA后 ,大鼠平均动脉压升高 ,延髓头端腹外侧区 (RVLM)内Ach含量增多 ,且这一升压效应可被PAG内预注L Arg或RVLM内预注东莨菪碱所阻断。 Objective To study the role and mechanism of NO in midbrain periaqueductal gray(PAG) on blood pressure in rat.Methods The changes of blood pressure were observed by microinjection method.The content of Ach was detected by using radioimmunoassay.Results Following microinjection of L NNA into PAG,the mean arterial pressure and the content of Ach in rostral vertrolateral medulla(RVLM) increased in rats.The pressor effect of L NNA could be blocked by preinjection of L Arg into PAG or scopolamine into RVLM.Conclusion NO in PAG may tonically inhibit blood pressure,it may be mediated by Ach in RVLM.
作者 胡旺平 化长林 黄碧兰 朱晓琴 余良主 金延安
机构地区 咸宁学院医学院生理学教研室
出处 《咸宁医学院学报》 2003年第1期13-16,共4页 Journal of Xianning Medical College
关键词 中脑导水管周围灰质 NO 大鼠 血压 影响 作用机制 乙酰胆碱 Midbrain periaqueductal gray Nitric oxide Blood pressure Acetylcholine
分类号 R544.1 [医药卫生—心血管疾病] R331.36 [医药卫生—人体生理学]
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参考文献6

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二级参考文献6

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共引文献8

同被引文献11

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引证文献1

咸宁医学院学报
2003年 第1期

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