肿瘤标志物谱对常见肿瘤的筛查意义

The significance of multiple tumor in screening of the tumor markers by union tests.

目的探讨用简单的肿瘤标志谱来筛查提高常见肿瘤的检出率。 方法 将甲胎蛋白(AFP)、癌胚抗原(CEA)、铁蛋白(Ft)、唾液酸(SA)组合为简单的肿瘤标志物谱——‘癌谱’,用定量ELISA法检测‘癌谱’中的AFP、CEA、Ft,用化学法检测SA。将临床确诊的各类常见肿瘤病人,良性疾病人群及健康体检人群作“癌谱”测定,结果经统计分析作肿瘤诊断的阳性率、特异性、阳性预测值、阴性预测值评价。 结果 ‘癌谱’对肿瘤组的阳性率为89.7％,特异性90.3％。阳性预测值90.1％,阴性预测值89.9％,常见肿瘤的灵敏度分别为:肝癌95.6％、肺癌(腺癌和鳞癌)92.1％、胃癌86.6％、直结肠癌81.6％、乳腺癌84.2％、绒癌93.8％、卵巢癌88％。结论“癌谱”是一种筛查常见肿瘤的简单、廉价的实验室方法。

Objective To study the sensitivity of multiple malignant tumor(MMT) by simple tumor markers union tests. Methods a-fetoprotein(AFP), Carcinoembryonic antigen(CEA), Ferritin(Ft) and Sialic acid(SA) were made up of a series of tumor markers union test-'STMUT', AFP, CEA, Ft with quantitative determination by ELISA and SA by chemistry measurement method. 'STMUT' detection was performed in the patients with MMT, benign diseases and the health persons, then MMT diagnostic positive rate, specificity and the value of positive and negative prediction were assessed respetively. Results Total positive rate, specificity, positive predictive value and negative predictive value were 89.7%,90.3%,90.1% and 89.9% respectively in MMT group, the positive rate were 95.6%,92.1%,86.6%,81.6%,84.2%,93.8% and 88% for hepatocarcinoma, lung cancer gastric-carcinoma, recto-/colocancer, breast cancer, choriocarcinoma and ovarian carcinoma. Conclusion 'STMUT' is a kind of simple, cheap laboratory screening assay for MMT.