二烃基锡二茂铁羧酸酯的合成及研究

Syntheses and Study of Diorganotin Ferrocenoates

通过二烃基氧化锡与取代二茂铁羧酸缩合 ,合成 14个未见文献报道的二烃基锡二茂铁羧酸酯化合物 .通过对化合物的核磁共振谱、红外光谱、元素分析的研究 ,确定化合物的组成和结构及形成结构的原因 .化合物 12的X衍射单晶测定表明 ,化合物是以Sn2 O2 四元环为中心的中心对称二聚体结构、内环锡为 5配位的畸变三角双锥结构、外环锡为 6配位的畸变八面体结构 .化合物的抗癌活性实验结果表明 ,部分化合物有较高的抗KB肿瘤细胞和抗Bel 740 2肿瘤细胞活性 .

Fourteen new diorganotin carboxylates were synthesized by the condensations of diorganotin oxide and substituted-ferrocenyl carboxylic acid. The structures of the products were determined by H-1 NMR, IR and elemental analysis. The struture of compound 12 was determined by X-ray crystallography analysis. The molecule is, centrosymmetric diner and has a core of Sn2O2 unit. The endocyclic Sn atoms exist in a distorted triginal bipyramidal geometry with the coordination number of 5. The exocyclic Sn atoms form 6 significant bonds and exist in a distorted octahedron geometry. The results of antitumor tests showed that some of the products have high inhibiting activity for KB cells and Bel-7402 cells.