5,3′,4′-三羟基-6,7-二甲氧基黄酮的另法全合成

A Modified Synthesis of 5,3′,4′-Trihydroxyl-6,7-dimethoxyflavone

从两个易得原料 3 ,4,5 三甲氧基苯甲酸和 3 ,4 二羟基苯甲醛出发 ,分别合成出 2 羟基 4,5 ,6 三甲氧基苯乙酮和 3 ,4 二苄氧基苯甲酰氯 ,随后采用相转移催化法成功地全合成了 5 ,3′ ,4′ 三羟基 6,7 二甲氧基黄酮 .

2-Hydroxy-4,5,6-trimethoxyacetophenone and 3,4-benzyloxybenzoyl chloride were prepared from readily available I chemicals, 3,4,5-trimethoxybenzoic acid and 3,4-dihydroxybenzaldehyde, respectively. 5,3',4'-Trihydroxyl-6,7-dimethoxyflavone was obtained by the reaction these two key intermediates under a PTC conditions.