恶性淋巴瘤和正常淋巴结中核仁组成区相关蛋白的研究

Study on Nucleolar Organiser Regions Associated Proteins in Malignant Lymphomas and Normal Lymph Nodes

采用嗜银染技术对23例恶性淋巴瘤、8例淋巴结反应性增生和10例正常淋巴结的核仁组成区相关蛋白进行了显示(AgNOR)。结果显示恶性淋巴瘤的AgNOR核均数较高,与正常淋巴结和反应性淋巴结增生相比较有非常显著性差异(P<0.01)。不同恶性程度的非何杰金氏恶性淋巴瘤的AgNOR之间也有差异(P<0.05或P<0.01)。AgNOR方法有助于鉴别淋巴结的良恶性病变,在对恶性淋巴瘤的诊断和分型上有一定价值。

An argyrophil technique for the demonstration of nucleolar organiser region (AgNOR) was applied to 23 specimens of malignant lymphomas, 8 reactive lymphaden proliferation and 10 normal lymph nodes. The results showed that mean AgNOR per nucleus in malignant lymphomas was high. There was significant difference (P<0.01)between the AgNOR per nucleus in malignant lymphomas and those in normal lymph nodes and reactive lymphaden proliferation. There was also difference (P<0.05 or P<0.01)among the AgNOR per nucleus in different malignant degrees of malignant NonHodgkin's lymphomas. AgNOR method, which is to assist in discrimination between malignant and benign lymph node diseases, had potential in both diagnosis and typing of lymphomas.