25例妊娠合并甲状腺功能亢进临床分析

Clinical Analysis on 52 Gestations with Hyperthyroidism

目的 评价妊娠合并甲状腺功能亢进患者孕期病情变化对妊娠结局的影响。方法 对 2 5例妊娠合并甲状腺功能亢进病例作回顾性分析。结果 2 5例除 10例孕前甲状腺功能亢进已控制 ,孕期无明显甲状腺功能亢进外 ,其余 15例孕期均发生显著的甲状腺功能亢进症状。前 10例患者无明显母婴异常 ,后 15例中初发 5例 ,加重 3例 ,复发 7例 ;孕早期发病 7例 (4 6.67% ) ,孕中、晚期发病 8例 (5 3 .3 3 % ) ;2例 (13 .3 3 % )发生早产 ;6例 (4 0 % )发生胎儿宫内发育迟缓 (I UGR) ;3例 (2 0 % )发生妊高征 ,2例 (8% )发生羊水过少 ,3例 (2 0 % )发生胎盘功能低下 ;而且这 15例新生儿中发生窒息2例 (8% ) ,发生新生儿甲状腺功能减退 3例 (2 0 % )。结论 妊娠各期甲状腺功能亢进均可能加重 ,尤其多见于孕中、晚期 ;甲状腺功能亢进可导致不良妊娠结局 ,并对胎儿及新生儿产生不良影响 ,故应加强早期监护。

Objective To evaluate effects of change of gestational period conditions on gestational finale. Method 25 gestation with Hyperthyroidism were retrospectively analyzed. Result Of the 25 cases, except the 10 hyperthyroidism that had been under control prior to pregnancy and no significant signs detected during pregnancy, the rest 15 cases showed significant syndrome. No obvious abnormity was found in mothers and babies. Of the latter 15 cases 3 turned serious and there were 5 incipiencies, 7 relapses and 7 onsets at early stage of pregnancy(46.67%)8 onsets during mid and final pregnancy (53.33%); 2 premature labors (13.33%); 6 (40%) IUGRs, 3 (20%) PIHs; 2 (8%) hypamnions; of the latter 15 cases, 3 (20%) placenta hypofunctions; and there were two newborn asphyxias (8%) and 3 (20%) newborn hypothyroidism Conclusion Hypothyroidism can become serious at all stages of pregnancy, especially at mid and final periods; It can lead to defective gestation finale, therefore monitoring at early stage and timely treatment should be taken.