不同浓度米非司酮对体外培养子宫肌瘤细胞生长的影响

Effect of Different Concentrations of Mifepristone on Human Uterine Leiomyoma Cells in Vitro

目的 :观察米非司酮对体外培养子宫肌瘤细胞的作用。方法 :采用绘制细胞生长曲线和MTT法检测了解不同浓度米非司酮对体外培养子宫肌瘤细胞生长的影响。结果 :低浓度米非司酮对子宫肌瘤细胞无抑制作用 ,当药物浓度达到 10 - 6mol L时其作用才表现出来 ,随着浓度的增加 ,其抑制作用增强。结论 :米非司酮对子宫肌瘤细胞的作用具有浓度依赖关系。

Objective:To observe the effect of mifepristone on the human uterine leiomyoma cells in vitro. Methods :Human uterine leiomyoma cells were treated with mifepristone at different concentrations and the growth of the cells was analyzed by plotting cell growth curve and MTT assay.Results:Lower concentration of mifepristone had no inhibitory effect on the human uterine leiomyoma cells, The effect developed when the concentration was up to 16 -6 mol/L,and the inhibitory effect of mifepristone became more significant with the increase of the concentration.Conclusions:The effect of mifepristone on human leiomyoma cells in vitro is concentration-dependent.